{"source":"reg-pharma","note":"Free 5-item preview. The full feed is $0.05/call at GET /v1/reg-pharma/changes.","question":"Which final or proposed federal rules affecting prescription drugs & biologics (drug, biologic, nda, anda, clinical) were published since T, and which carry compliance obligations?","sample":[{"source":"reg-pharma","entityId":"fedreg:2026-14573","type":"final_rule","title":"Food Standards of Identity Modernization; Pasteurized Orange Juice","summary":"The Food and Drug Administration (FDA or we) is issuing a final rule to amend the standard of identity for pasteurized orange juice by lowering the minimum orange juice soluble solids content from 10.5[deg] to 10[deg] Brix and permitting up to 15 percent Citrus reticulata juice or Citrus reticulata hybrid juice, by volume. This final rule modernizes the pasteurized orange juice standard. This action responds to two citizen petitions: one submitted by the Florida Citrus Processors Association Inc. and the Florida Citrus Mutual Inc., and another submitted by the Florida Department of Citrus, th…","significance":6,"detectedAt":"2026-07-18T23:39:51.315Z","effectiveDate":"2026-08-19","sourceUrl":"https://www.federalregister.gov/documents/2026/07/20/2026-14573/food-standards-of-identity-modernization-pasteurized-orange-juice","detail":{"documentNumber":"2026-14573","documentType":"Rule","agencies":"Health and Human Services Department, Food and Drug Administration","publicationDate":"2026-07-20","vertical":"reg-pharma"}},{"source":"reg-pharma","entityId":"fedreg:2026-14450","type":"proposed_rule","title":"Endangered and Threatened Wildlife and Plants; Grizzly Bear Listing on the List of Endangered and Threatened Wildlife With a Revised Section 4(d) Rule; Proposed Revision of the Protective Regulations…","summary":"We, the U.S. Fish and Wildlife Service (Service or FWS), notify the public that we are making changes to our January 15, 2025, proposed rule to revise the protective regulations for the grizzly bear (Ursus arctos horribilis) in the lower-48 States under section 4(d) of the Endangered Species Act of 1973, as amended (Act or ESA). We are reopening the comment period because we are proposing substantive changes to the protective regulations in the January 15, 2025, proposed rule. Comments previously submitted will be considered and do not need to be resubmitted now. However, we invite comments o…","significance":4,"detectedAt":"2026-07-18T23:39:51.315Z","effectiveDate":null,"sourceUrl":"https://www.federalregister.gov/documents/2026/07/17/2026-14450/endangered-and-threatened-wildlife-and-plants-grizzly-bear-listing-on-the-list-of-endangered-and","detail":{"documentNumber":"2026-14450","documentType":"Proposed Rule","agencies":"Interior Department, Fish and Wildlife Service","publicationDate":"2026-07-17","vertical":"reg-pharma"}},{"source":"reg-pharma","entityId":"fedreg:2026-14492","type":"final_rule","title":"Endangered and Threatened Wildlife and Plants; Reclassification of the Razorback Sucker From Endangered to Threatened With a Section 4(d) Rule","summary":"We, the U.S. Fish and Wildlife Service (Service), are reclassifying the razorback sucker (Xyrauchen texanus) from endangered to threatened (downlist) under the Endangered Species Act of 1973, as amended (Act). This action is based on our evaluation of the best scientific and commercial data available, which indicates that the species' status has improved such that it is not currently in danger of extinction throughout all or a significant portion of its range, but that it is still likely to become so within the foreseeable future. We also finalize protective regulations under the authority of…","significance":7,"detectedAt":"2026-07-18T23:39:51.314Z","effectiveDate":"2026-08-17","sourceUrl":"https://www.federalregister.gov/documents/2026/07/17/2026-14492/endangered-and-threatened-wildlife-and-plants-reclassification-of-the-razorback-sucker-from","detail":{"documentNumber":"2026-14492","documentType":"Rule","agencies":"Interior Department, Fish and Wildlife Service","publicationDate":"2026-07-17","vertical":"reg-pharma"}},{"source":"reg-pharma","entityId":"fedreg:2026-14550","type":"final_rule","title":"Endangered and Threatened Wildlife and Plants; Reclassification of the Hawaiian Stilt (Kukuluae'o or Ae'o) From Endangered to Threatened With a Section 4(d) Rule","summary":"We, the U.S. Fish and Wildlife Service (Service), are reclassifying the Hawaiian stilt (kukuluae[revaps]o or ae[revaps]o, Himantopus mexicanus knudseni; a subspecies of the black-necked stilt (Himantopus mexicanus)) from endangered to threatened (downlist) under the Endangered Species Act of 1973, as amended (Act). This action is based on our evaluation of the best scientific and commercial data available, which indicates that the subspecies' status has improved such that it is not in danger of extinction throughout all or a significant portion of its range, but that it is still likely to bec…","significance":7,"detectedAt":"2026-07-18T23:39:51.314Z","effectiveDate":"2026-08-19","sourceUrl":"https://www.federalregister.gov/documents/2026/07/20/2026-14550/endangered-and-threatened-wildlife-and-plants-reclassification-of-the-hawaiian-stilt-kukuluaeo-or","detail":{"documentNumber":"2026-14550","documentType":"Rule","agencies":"Interior Department, Fish and Wildlife Service","publicationDate":"2026-07-20","vertical":"reg-pharma"}},{"source":"reg-pharma","entityId":"fedreg:2026-13440","type":"proposed_rule","title":"Enabling Supersonic Overland Flight","summary":"This proposal would advance the United States' leadership in next-generation aviation by replacing the longstanding prohibition on civil supersonic flight over land with a modern, performance-based regulatory framework. Consistent with national policy set forth by the Executive Order of June 6, 2025, Leading the World in Supersonic Flight, this action would enable the safe, efficient, and commercially viable operation of civil supersonic aircraft in the United States. Current regulations prohibit flight operations of civil aircraft at a true flight Mach number greater than 1 in the U.S., exce…","significance":6,"detectedAt":"2026-07-16T20:32:48.553Z","effectiveDate":null,"sourceUrl":"https://www.federalregister.gov/documents/2026/07/02/2026-13440/enabling-supersonic-overland-flight","detail":{"documentNumber":"2026-13440","documentType":"Proposed Rule","agencies":"Transportation Department, Federal Aviation Administration","publicationDate":"2026-07-02","vertical":"reg-pharma"}}]}